2024 | Understanding Voriconazole Metabolism: A Middle‑Out Physiologically‑Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights | A. Saleh, J. Schulz, J.‑F. Schlender, L. B. S. Aulin, A.‑P. Konrad, F. Kluwe, G. Mikus, W. Huisinga, C. Kloft, R. Michelet
Zeitschrift: Clinical Pharmacokinetics Link zur Publikation

2024 | A Hands-on Guide to AmoePy — a Python-Based Software Package to Analyze Cell Migration Data | T. Moldenhawer, D. Schindler, M. Holschneider, W. Huisinga, C. Beta
Reihe: Methods in Molecular Biology Verlag: Springer Nature Buchtitel: Cell Motility and Chemotaxis Seiten: 159-184 Band: 2828 Link zur Publikation

2024 | Novel mathematical approach to accurately quantify 3D endothelial cell morphology and vessel geometry based on fluorescently marked endothelial cell contours: Application to the dorsal aorta of wild-type and Endoglin-deficient zebrafish embryos | D. Seeler, N. Grdseloff, C. J. Rödel, C. Kloft, S. Abdelilah-Seyfried, W. Huisinga
Zeitschrift: PLoS Computational Biology Link zur Publikation

2024 | Leveraging QSP Models for MIPD: A Case Study for Warfarin/INR | U. Falkenhagen, L. H. Cavallari, J. D. Duarte, C. Kloft, S. Schmidt, W. Huisinga
Zeitschrift: Clinical Pharmacology & Therapeutics Seiten: 795-806 Band: 116(3) Link zur Publikation

2024 | Calcium kinetic rates in Caucasian males and females from birth to adulthood | N. Hartung, S. A. Abrams, W. Huisinga, K. Weisser
Zeitschrift: Bone Link zur Publikation

2024 | Model reduction for Ca2+-induced vesicle fusion dynamics | A. Ernst, U. Falkenhagen, S. Winkelmann
Zeitschrift: Proceedings in Applied Mathematics and Mechanics Seiten: e202300184 Link zur Publikation

2024 | Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions | D. Schindler, T. Moldenhawer, C. Beta, W. Huisinga, M. Holschneider
Zeitschrift: PLoS One Link zur Publikation , Link zum Preprint

2024 | Index analysis: an approach to understand signal transduction with application to the EGFR signalling pathway | J. Knöchel, C. Kloft, W. Huisinga
Zeitschrift: PLoS Computational Biology Link zur Publikation , Link zum Preprint

2023 | Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data | F. Kluwe. R. Michelet, W. Huisinga, M. Zeitlinger, G. Mikus, C. Kloft
Zeitschrift: Clinical Pharmacokinetics Link zur Publikation

2023 | C-Reactive Protein as an Early Predictor of Efficacy in Advanced Non-Small-Cell Lung Cancer Patients: A Tumor Dynamics-Biomarker Modeling Framework | Y. M. Nassar, F. W. Ojara, A. Pérez-Pitarch, K. Geiger, W. Huisinga, N. Hartung, R. Michelet, S. Holdenrieder, M. Joerger, C. Kloft
Zeitschrift: Cancers Seiten: 5429 Band: 15(22) Link zur Publikation

2023 | Sample-based robust model reduction for non-linear systems biology models | U. Falkenhagen, C. Himpe, J. Knöchel, C. Kloft, W. Huisinga
Zeitschrift: Proceedings in Applied Mathematics & Mechanics Link zur Publikation

2023 | Deriving mechanism-based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin | U. Falkenhagen, J. Knöchel, C. Kloft, W. Huisinga
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Seiten: 432–443 Band: 12 Link zur Publikation

2023 | Model-Informed Target Morning 17α-Hydroxyprogesterone Concentrations in Dried Blood Spots for Pediatric Congenital Adrenal Hyperplasia Patients | V. Stachanow, U. Neumann, O. Blankenstein, N. Alder-Baerens, D. Bindellini, P. Hindmarsh, R.J. Ross, M.J. Whitaker, J. Melin, W. Huisinga, R. Michelet, C. Kloft
Zeitschrift: Pharmaceuticals Seiten: 464 Band: 16(3) Link zur Publikation

2023 | Cell-level systems biology model to study inflammatory bowel diseases and their treatment options | S. Stübler, C. Kloft, W. Huisinga
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Seiten: 690-705 Band: 12 Link zur Publikation

2023 | A prognostic baseline blood biomarker and tumor growth kinetics integrated model in paclitaxel/platinum treated advanced non-small cell lung cancer patients | F. W. Ojara, A. Henrich, N. Frances, Y. M. Nassar, W. Huisinga, N. Hartung, K. Geiger, S. Holdenrieder, M. Joerger, C. Kloft
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Link zur Publikation

2023 | Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach | R. Michelet, D. Bindellini, J. Melin, U. Neumann, O. Blankenstein, W. Huisinga, T. Johnson, M. J. Whitaker, R. Ross, C. Kloft
Zeitschrift: Frontiers in Pharmacology Seiten: 1090554 Band: 13 Link zur Publikation

2022 | Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion | Y. M. Nasser, N. Hohmann, R. Michelet, K. Gottwalt, A. D. Meid, J. Burhenne, W. Huisinga, W. E. Haefeli, G. Mikus, C. Kloft
Zeitschrift: Clinical Pharmacokinetics Reihe: 61 Seiten: 1595–1607 Link zur Publikation

2022 | Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review | A. Démaris, E. S. K. Widigson, J. F. K. F. Ilvemark, C. Steenholdt, J. B. Seidelin, W. Huisinga, R. Michelet, L. B. S. Aulin, C. Kloft
Zeitschrift: Pharmaceutics Seiten: 2095 Band: 14 Link zur Publikation

2022 | A continued learning approach for model-informed precision dosing: updating models in clinical practice | C. Maier, J. de Wiljes, N. Hartung, C. Kloft, W. Huisinga
Zeitschrift: CPT: Pharmacometrics Syst. Pharmacol. Seiten: 185-198 Band: 11 Link zur Publikation , Link zum Preprint

2022 | Exploring dried blood spot cortisol concentrations as an alternative for monitoring pediatric adrenal insufficiency patients: A model-based analysis | V. Stachanow, U. Neumann, O. Blankenstein, D. Bindellini, J. Melin, R. Ross, M.J. Whitaker, W. Huisinga, R. Michelet, C. Kloft
Zeitschrift: Frontiers Pharmacol. Seiten: 1-8 Band: 13 Link zur Publikation

2022 | High-dosage fosfomycin results in adequate plasma and target-site exposure in morbidly obese and nonobese nonhyperfiltration patients | D. Busse, P. Simon, D. Petroff, N. El-Najjar, L. Schmitt, D. Bindellini, A. Dietrich, M. Zeitlinger, W. Huisinga, R. Michelet, H. Wrigge, C. Kloft
Zeitschrift: Antimicrob. Agents Chemother. Seiten: e0230221 Band: 66 Link zur Publikation

2022 | Comparative plasma and interstitial tissue fluid pharmacokinetics of meropenem demonstrate the need for increasing dose and infusion duration in obese and non-obese patients | D. Busse, P. Simon, L. Schmitt, D. Petroff, C. Dorn, A. Dietrich, M. Zeitlinger, W. Huisinga, R. Michelet, H. Wrigge, C. Kloft
Zeitschrift: Clin. Pharmacokinet. Seiten: 655-672 Band: 61 Link zur Publikation

2022 | Evaluation of a meropenem and piperacillin monitoring program in intensive care unit patients calls for the regular assessment of empirical targets and easy-to-use dosing decision tools | F.A. Weinelt, M.S. Stegemann, A. Theloe, F. Pfäfflin, S. Achterberg, F. Weber, L. Dübel, A. Mikolajewska, A. Uhrig, P. Kiessling, W. Huisinga, R. Michelet, S. Hennig, C. Kloft
Zeitschrift: Antibiotics Seiten: 758 Band: 11(6) Link zur Publikation

2022 | Spontaneous transitions between amoeboid and keratocyte-like modes of migration | T. Moldenhawer, E. Moreno, D. Schindler, S. Flemming, M. Holschneider, W. Huisinga, S. Alonso, C. Beta
Zeitschrift: Front. Cell Dev. Biol. Seiten: 10:898351 Link zur Publikation

2021 | Mit Mathematik zur individuellen Therapie | W. Huisinga, C. Maier
Buchtitel: M. Ehrhardt, M. Günther und W. Schilders: Erfolgsformeln - Anwendungen der Mathematik Seiten: 27-32 Link zur Publikation

2021 | Reinforcement learning and Bayesian data assimilation for model-informed precision dosing in oncology | C. Maier, N. Hartung, C. Kloft, W. Huisinga, J. de Wiljes
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Seiten: 241–254 Band: 10 Link zur Publikation , Link zum Preprint

2021 | Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Reponse Exemplified by Levofloxacin | D. Busse, A. Schaeftlein, A. Solms, L. Ilia, R. Michelet, M. Zeitlinger, W. Huisinga, C. Kloft
Zeitschrift: Pharmaceutical Research Seiten: 381-395 Band: 38 Link zur Publikation

2021 | Quantification of microdialysis related variability in humans: Clinical trial design recommendations | D. Busse, P. Simon, R. Michelet, L. Ehmann, F. Mehner, C. Dorn, A. Kratzer, W. Huisinga, H. Wrigge, D. Petroff, C. Kloft
Zeitschrift: European Journal of Pharmaceutical Sciences Seiten: 105607 Band: 157 Link zur Publikation

2021 | Analysis of protrusion dynamics in amoeboid cell motility by means of regularized contour flows | D. Schindler, T. Moldenhawer, M. Stange, C. Beta, M. Holschneider, W. Huisinga
Zeitschrift: PLoS Computational Biology Seiten: e1009268 Band: 17(8) Link zur Publikation

2021 | Physiology-based toxicokinetic modelling of aluminium in rat and man | C. Hethey, N. Hartung, G. Wangorsch, K. Weisser, W. Huisinga
Zeitschrift: Archives of Toxicology Seiten: 2977–3000 Band: 95 Link zur Publikation

2021 | Evaluating prediction methods for glomerular filtration to optimise drug doses in obese and nonobese patients | D. Busse, J.M. Borghardt, D. Petroff, A. Pevzner, C. Dorn, N. El-Najjar, W. Huisinga, H. Wrigge, P. Simon, C. Kloft
Zeitschrift: British Journal of Clinical Pharmacology Seiten: 2973-2981 Band: 88 Link zur Publikation

2021 | Development of a model-informed dosing tool to optimise initial antibiotic dosing - a translational example for intensive care units | F. Weinelt, M. Stegemann, A. Theloe, F. Pfäfflin, S. Achterberg, L. Schmitt, W. Husinga, R. Michelet, S. Hennig, C. Kloft
Zeitschrift: Pharmaceutics Seiten: 2128 Band: 13 Link zur Publikation

2021 | Correction to: Therapeutic drug monitoring of oral targeted antineoplastic drugs | A. Mueller-Schoell, S.L. Groenland, O. Scherf-Clavel, M. van Dyk, W. Huisinga, R. Michelet, U. Jaehde, N. Steeghs, A.D.R. Huitema, C. Kloft
Zeitschrift: Eur. J. Clin. Pharmacol. Seiten: 465 Band: 77 Link zur Publikation

2021 | Therapeutic drug monitoring of oral targeted antineoplastic drugs | A. Mueller-Schoell, S.L. Groenland, O. Scherf-Clavel, M. van Dyk, W. Huisinga, R. Michelet, U. Jaehde, N. Steeghs, A.D.R. Huitema, C. Kloft
Zeitschrift: Eur. J. Clin. Pharmacol. Seiten: 441-464 Band: 77 Link zur Publikation

2021 | Infliximab clearance decreases in second and third trimesters of pregnancy in inflammatory bowel disease | A.M. Grisic, M. Dorn-Rasmussen, B. Ungar, J. Brynskov, J.F. Ilvemark, N. Bolstad, D.J. Warren, M.A. Ainsworth, W. Huisinga, S. Ben-Horin, C. Kloft, C. Steenholdt
Zeitschrift: United Eur. Gastroenterol. J. Seiten: 91-101 Band: 9 Link zur Publikation

2021 | Evaluation of the MeroRisk Calculator, a user-friendly tool to predict the risk of meropenem target non-attainment in critically ill patients | U. Liebchen, M. Klose, M. Paal, M. Vogeser, M. Zoller, I. Schroeder, L. Schmitt, W. Huisinga, R. Michelet, J. Zander, C. Scharf, F. Weinelt, C. Kloft
Zeitschrift: Antibiotics Reihe: 10 Seiten: 468 Link zur Publikation

2021 | Similar piperacillin/tazobactam target attainment in obese versus nonobese patients despite differences in interstitial tissue fluid pharmacokinetics | D. Busse, P. Simon, D. Petroff, C. Dorn, L. Schmitt, D. Bindellini, A. Kratzer, A. Dietrich, M. Zeitlinger, W. Huisinga, R. Michelet, H. Wrigge, C. Kloft
Zeitschrift: Pharmaceuticals Reihe: 13 Seiten: 1380 Link zur Publikation

2021 | Early survival prediction framework in CD19-specific CAR-T-cell immunotherapy using a population quantitative systems pharmacology model | A. Mueller-Schoell, N. Puebla-Osorio, R. Michelet, M. Green, A. Künkele, W. Huisinga, P. Strati, B. Chasen, S.S. Neelapu, C. Yee, C. Kloft
Zeitschrift: Cancers Reihe: 13 Seiten: 2782 Link zur Publikation

2021 | Simulation-based assessment of the impact of non-adherence on endoxifen target attainment in different tamoxifen dosing strategies | A. Mueller-Schoell, L. Klopp-Schulze, R. Michelet, M. Van Dyk, T.E. Mürdter, M. Schwab, M. Joerger, W. Huisinga, G. Mikus, C. Kloft
Zeitschrift: Pharmaceuticals Reihe: 14 Seiten: 115 Link zur Publikation

2021 | Computational treatment simulations to assess the need for personalized tamoxifen dosing in breast cancer patients of different biogeographical groups | A. Mueller-Schoell, R. Michelet, L. Klopp-Schulze, M. van Dyk, T.E. Mürdter, M. Schwab, M. Joerger, W. Huisinga, G. Mikus, C. Kloft
Zeitschrift: Cancers Reihe: 13 Seiten: 2432 Link zur Publikation

2021 | Rationale of a lower dexamethasone dose in prenatal congenital adrenal hyperplasia therapy based on pharmacokinetic modelling | V. Stachanow, U. Neumann, O. Blankenstein, U. Fuhr, W. Huisinga, R. Michelet, N. Reisch, C. Kloft
Zeitschrift: European Journal of Endocrinology Seiten: 365–374 Band: 185:3 Link zur Publikation

2021 | Nonparametric goodness-of-fit testing for parametric covariate models in pharmacometric analyses | N. Hartung, M. Wahl, A. Rastogi, W. Huisinga
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Seiten: 564–576 Band: 10 Link zur Publikation , Link zum Preprint

2021 | Quantitative relationship between infliximab exposure and inhibition of C‐reactive protein synthesis to support inflammatory bowel disease management | A.‐M. Grisic, A. Eser, W. Huisinga, W. Reinisch, C. Kloft
Zeitschrift: British Journal of Clinical Pharmacology Seiten: 2374-2384 Band: 87 Link zur Publikation

2021 | Perspectives on model-informed precision dosing in the digital health era: Challenges, opportunities, and recommendations | F. Kluwe, R. Michelet, A. Mueller-Schoell, C. Maier, L. Klopp-Schulze, M. van Dyk, G. Mikus, W. Huisinga, C. Kloft
Zeitschrift: Clinical Pharmacology & Therapeutics Seiten: 29-36 Band: 109 Link zur Publikation

2020 | Pharmacokinetic/pharmacodynamic evaluation of hydrocortisone therapy in pediatric patients with congenital adrenal hyperplasia | J. Melin, Z.P. Parra-Guillen, R. Michelet, T. Truong, W. Huisinga, N. Hartung, P. Hindmarsh, C. Kloft
Zeitschrift: The Journal of Clinical Endocrinology & Metabolism Link zur Publikation

2020 | Tikhonov regularization with oversmoothing penalty for nonlinear statistical inverse problems | A. Rastogi
Zeitschrift: Communications on Pure & Applied Analysis Seiten: 4111-4126 Band: 19 (8) Link zur Publikation

2020 | Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study | A.-M. Grisic, A. Khandelwal, M. Bertolino, W. Huisinga, P. Girard, C. Kloft
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Seiten: 628–638 Band: 9 Link zur Publikation

2020 | Risk of target non-attainment in obese compared to non-obese patients in calculated linezolid therapy | L. Ehmann, P. Simon, D. Busse, D. Petroff, C. Dorn, W. Huisinga, A. Dietrich, M. Zeitlinger, H. Wrigge, C. Kloft
Zeitschrift: Clinical Microbiology and Infection Seiten: 1222-1228 Band: 26 Link zur Publikation

2020 | Response to ‘Hydrocortisone suspension formulations are not necessarily the same in the treatment of children with congenital adrenal hyperplasia’. | R. Michelet, J. Melin, Z.P. Parra-Guillen, U. Neumann, M.J. Whitaker, V. Stachanow, W. Huisinga, J. Porter, O. Blankenstein, R.J. Ross, C. Kloft
Zeitschrift: European Journal of Endocrinology Seiten: L29-L30 Band: 183 Link zur Publikation

2020 | Convergence analysis of Tikhonov regularization for non-linear statistical inverse learning problems | A. Rastogi, G. Blanchard, P. Mathé.
Zeitschrift: Electronic Journal of Statistics Seiten: 2798-2841 Band: 14 (2) Link zur Publikation , Link zum Preprint

2020 | A mechanistic framework for a priori pharmacokinetic predictions of orally inhaled drugs | N. Hartung, J. Borghardt
Zeitschrift: PLoS Computational Biology Link zur Publikation , Link zum Preprint

2020 | Time-to-event analysis of paclitaxel-associated peripheral neuropathy in advanced non-small cell lung cancer highlighting key influential treatment/patient factors | F.W. Ojara, A. Henrich, N. Frances, W. Huisinga, N. Hartung, M. Joerger, C. Kloft
Zeitschrift: Journal of Pharmacology and Experimental Therapeutics Seiten: JPET-AR-2020-000053 Link zur Publikation

2020 | Paediatric population pharmacokinetic modelling to assess hydrocortisone replacement dosing regimens in young children | R. Michelet, J. Melin, Z.P. Parra-Guillen, U. Neumann, M.J. Whitaker, V. Stachanow, W. Huisinga, J. Porter, O. Blankenstein, R.J. Ross, C. Kloft
Zeitschrift: European Journal of Endocrinology Seiten: 357–368 Band: 183 Link zur Publikation

2020 | Obesity Alters Endoxifen Plasma Levels in Young Breast Cancer Patients: A Pharmacometric Simulation Approach | A. Mueller‐Schoell, L. Klopp‐Schulze, W. Schroth, T. Mürdter, R. Michelet, H. Brauch, W. Huisinga, M. Joerger, P. Neven, S.L.W. Koolen, R.H.J. Mathijssen, E. Copson, D. Eccles, S. Chen, B. Chowbay, A. Tfayli, N.K. Zgheib, M. Schwab, C. Kloft
Zeitschrift: Clinical Pharmacology & Therapeutics Link zur Publikation

2020 | Inverse learning in Hilbert scales | A. Rastogi, P. Mathé
Link zum Preprint

2020 | Bayesian data assimilation to support informed decision‐making in individualized chemotherapy | C. Maier, N. Hartung, J. de Wiljes, C. Kloft, W. Huisinga
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Link zur Publikation

2019 | Tikhonov regularization with oversmoothing penalty for linear statistical inverse learning problems. | A. Rastogi
Zeitschrift: AIP Conference Proceedings. Verlag: AIP Publishing LLC Band: 2183 (1) Link zur Publikation

2019 | Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics 17 (5):593–606, Sep/Oct 2018, DOI: 10.1002/pst.1873 | A. Krause, C. Kloft, W. Huisinga, M. Karlsson, J. Pinheiro, R. Bies, J. Rogers, F. Mentré, B.J. Musser, ASA Special Interest Group on Statistics and Pharmacometrics/ASA Special Interest Group on Statistics and Pharmacometrics (SIG SxP)
Zeitschrift: Pharmaceutical Statistics Seiten: 278–281 Band: 18 Link zur Publikation

2019 | Development of a dosing algorithm for meropenem in critically ill patients based on a population pharmacokinetic/pharmacodynamic analysis. | L. Ehmann, M. Zoller, I.K. Minichmayr, C. Scharf, W. Huisinga, J. Zander, C. Kloft
Zeitschrift: Int. J. Antimicrob. Agents Seiten: 309-317 Band: 54 Link zur Publikation

2019 | The circadian rhythm of corticosteroid-binding globulin has little impact on cortisol exposure after hydrocortisone dosing | J. Melin, N. Hartung, Z.P. Parra-Guillen, M.J. Whitaker, R.J. Ross, C. Kloft
Zeitschrift: Clinical Endocrinology Link zur Publikation

2018 | Stochastic and Deterministic Models for the Metastatic Emission Process: Formalisms and Crosslinks | C. Gomez, N. Hartung
Reihe: Methods Mol. Biol. Buchtitel: von Stechow L. (eds) Cancer Systems Biology Seiten: 193-224 Band: 1711 Link zur Publikation

2018 | Understanding and reducing complex systems pharmacology models based on a novel input-response index | J. Knöchel, C. Kloft, W. Huisinga
Zeitschrift: J Pharmacokinet Pharmacodyn Seiten: 139-157 Band: 45 Link zur Publikation , Suppl Material (Matlab code)

2017 | Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes | N. Hartung, U. Benary, J. Wolf, B. Kofahl
Zeitschrift: BMC Systems Biology Seiten: 98 Band: 11 Link zur Publikation

2017 | Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: A prospective observational study | L. Ehmann, M. Zoller, I. K. Minichmayr, C. Scharf, B. Maier, M. V. Schmitt, N. Hartung, W. Huisinga, M. Vogeser, L. Frey, J. Zander, C. Kloft
Zeitschrift: Critical Care Seiten: 263 Band: 21 Link zur Publikation

2017 | Impact of altered endogenous IgG on unspecific mAb clearance | S. Fuhrmann, C. Kloft, W. Huisinga
Zeitschrift: J Pharmacokinet Pharmacodyn Seiten: 351-374 Band: 44 Link zur Publikation ,

Suppl Material (Matlab code)

2017 | Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults | J. Melin, Z.P. Parra-Guillen, N. Hartung, W. Huisinga, R.J. Ross, M.J. Whitaker, C. Kloft
Zeitschrift: Clin Pharmacokinet. Verlag: Springer Link zur Publikation

2017 | Model Description Language (MDL): A Standard for Modelling and Simulation | M. Smith, S. Moodie, R. Bizzotto, E. Blaudez, E. Borella, L. Carrara, P. Chan, M. Chenel, E. Comets, R. Gieschke, K. Harling, L. Harnisch, N. Hartung, A. Hooker, M. Karlsson, R. Kaye, C. Kloft, N. Kokash, M. Lavielle, G. Lestini, P. Magni, A. Mari, F. Men
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Link zur Publikation ,

doi:10.1002/psp4.12222

2017 | Study of metastatic kinetics in metastatic melanoma treated with B-RAF inhibitors: Introducing mathematical modelling of kinetics into the therapeutic decision | N. Hartung, C.T. Huynh, C. Gaudy-Marqueste, A. Flavian, N. Malissen, M.A. Richard-Lallemand, F. Hubert, J.-J. Grob
Zeitschrift: PLoS ONE Band: 12(5) Link zur Publikation ,

e017608074

2017 | Towards toxicokinetic modelling of aluminium exposure from adjuvants in medicinal products | K. Weisser, S. Stübler, W. Matheis, W. Huisinga
Zeitschrift: Regul Toxicol Pharmacol Seiten: 310-321 Band: 88 Link zur Publikation

2017 | Magnitude of Increased Infliximab Clearance Imposed by Anti-infliximab Antibodies in Crohn's Disease Is Determined by Their Concentration | H. Edlund, C. Steenholdt, M.A. Ainsworth, E. Goebgen, J. Brynskov, O.Ø. Thomsen, W. Huisinga, C. Kloft
Zeitschrift: AAPS J Seiten: 223-233 Band: 19(1) Link zur Publikation

2017 | Translational Pharmacometric Evaluation of Typical Antibiotic Broad-Spectrum Combination Therapies Against Staphylococcus Aureus Exploiting In Vitro Information | S. Wicha, W. Huisinga, C. Kloft
Zeitschrift: CPT Pharmacometrics Syst Pharmacol Seiten: 512-522 Band: 6(8) Link zur Publikation

2017 | Semimechanistic Bone Marrow Exhaustion Pharmacokinetic/Pharmacodynamic Model for Chemotherapy-Induced Cumulative Neutropenia | A. Henrich A, M. Jörger, S. Kraff, U. Jaehde U, W. Huisinga, C. Kloft, Z.P. Parra-Guillen
Zeitschrift: J Pharmacol Exp Ther Seiten: 347-358 Band: 362(2) Link zur Publikation

2015 | Target driven pharmacokinetics of biopharmaceutics | W. Huisinga, S. Fuhrmann, L. Fronton, B.F. Krippendorff
Verlag: Wiley Buchtitel: 'Therapeutic Proteins – ADME and translational PK/PD in discovery and development', H. Zhou and F.-P. Theil (Eds.), ISBN 978-1-118-89864-2 Link zur Publikation

2014 | Estimating HIV-1 Fitness Characteristics from Cross-sectional Genotype Data | S. Gopalakrishnan, H. Montazeri, S. Menz, N. Beerenwinkel, W. Huisinga
Zeitschrift: PLoS Computational Biology Seiten: 1-14 Band: 10 Link zur Publikation ,

e1003886, Suppl Material (R and Matlab code)

2014 | Quantifying the degree of persistence in random amoeboid motion based on the Hurst exponent of fractional Brownian motion | N. Makarava, S. Menz, M. Theves, W. Huisinga, C. Beta, M. Holschneider
Zeitschrift: Phys Rev E 90, 042703 Link zur Publikation

2014 | Meta-analysis for diagnostic accuracy studies: A new statistical model using beta-binomial distributions and bivariate copulas | O. Kuß, A. Hoyer, A. Solms
Zeitschrift: Statistics in Medicine Seiten: 17-30 Band: 33 Link zur Publikation

2014 | Monoclonal antibody disposition: a simplified PBPK model and its implications for the derivation and interpretation of classical compartment models | L. Fronton, S. Pilari, W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 87-107 Band: 41 Link zur Publikation , Suppl Material (Matlab code)

2012 | Hybrid stochastic-deterministic solution of the chemical master equation | S. Menz, J.C. Latorre, C. Schütte, W. Huisinga
Zeitschrift: SIAM Multiscale Modelling and Simulation Seiten: 1232-1262 Band: 10 Link zur Publikation

2012 | Predicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modelling | B.-F. Krippendorff, D. A. Oyarzún, W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 125-139 Band: 39 Link zur Publikation

2012 | Modeling inter-individual variability in physiologically-based pharmacokinetics and its link to mechanistic covariate modeling | W. Huisinga, A. Solms, L. Fronton, S. Pilari
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Band: 1 Link zur Publikation , Suppl Material (Data and Matlab code)

2011 | Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock | S. Unverzagt, M.-T. Machemer, A. Solms, H. Thiele, D. Burkhoff, M. Seyfarth, A. de Waha, E. Magnus Ohman, Michael Buerke, Johannes Haerting, Karl Werdan, Roland Prondzinsky
Zeitschrift: Cochrane Database of Systematic Reviews 6, CD007398 Link zur Publikation

2011 | Gestational Influences on the Pharmacokinetics of Gestagenic Drugs: A Combined In Silico, In Vitro and In Vivo Analysis | S. Pilari, C. Preusse, W. Huisinga
Zeitschrift: Eur J Pharm Sci. Seiten: 318-331 Band: 42 Link zur Publikation

2011 | Logarithmic convergence rate of Levenberg_Marquardt method with application to an inverse potential problem | C. Böckmann, A. Kammanee, H.-A. Braunß
Zeitschrift: Journal of Inverse and III-Posed Problems Seiten: 345-367 Band: 19 Link zur Publikation

2011 | Error-Controlled Global Sensitivity Analysis of Ordinary Differential Equations | A. Y. Weiße, W. Huisinga
Zeitschrift: J. Comput. Phys. Seiten: 6824-6842 Band: 230 Link zur Publikation , Suppl Material (zip)

2011 | HIV Quasispecies Dynamics during Pro-Active Treatment Switching: Impact on Multi-Drug Resistance and Resistance Archiving in Latent Reservoirs | M. von Kleist, S. Menz, H. Stocker, K. Arasteh, C. Schütte, W. Huisinga
Zeitschrift: PLoS ONE Band: 6 Link zur Publikation , e18204

2010 | Drug-Class Specific Impact of Antivirals on the Reproductive Capacity of HIV | M. von Kleist, S. Menz, W. Huisinga
Zeitschrift: PLoS Comput Biol Band: 6(3) Link zur Publikation , e1000720

2010 | Quantifying uncertainty, variability and likelihood for ordinary differential equation models | A. Y. Weiße, R. Middleton, W. Huisinga
Zeitschrift: BMC Systems Biology Band: 4 Link zur Publikation

2010 | Lumping of Physiologically Based Pharmacokinetic Models and a Mechanistic Derivation of Classical Compartmental Models | S. Pilari, W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 365-405 Band: 37 Link zur Publikation

2010 | Eine gute Dosis Mathematik - Modellbasierte Arzneimittelentwicklung am Beispiel therapeutischer Proteine | W. Huisinga, B.-F. Krippendorff
Zeitschrift: Systembiologie.de, Ausg. 02, December 2010 Link zur Publikation

2009 | Nonlinear Pharmacokinetics of Therapeutic Proteins Resulting from Receptor Mediated Endocytosis | B.-F. Krippendorff, K. Küster, C. Kloft, W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 239-260 Band: 36 Link zur Publikation ,

Suppl Material

2009 | Ligand accumulation counteracts therapeutic inhibition of receptor systems | B.-F. Krippendorff, D. Oyarzun and W. Huisinga
Zeitschrift: Proceedings of Foundations of Systems Biology in Engeneering, FOSBE Seiten: 173-176 Link zur Publikation

2009 | Using math to optimize medication | W. Huisinga
Zeitschrift: NUI Maynooth Research Magazine, Vol. 1, January 2009 Link zur Publikation

2009 | Pharmacokinetic-Pharmacodynamic relationship of NRTIs and its connection to viral escape: An example based on Zidovudine | M. von Kleist, and W. Huisinga
Zeitschrift: Eur J Pharm Sci. Seiten: 532-543 Band: 36 Link zur Publikation

2009 | Mechanism-based Inhibition: Deriving KI and kinact directly from Time-Dependent IC50 Values | B.-F. Krippendorff, R. Neuhaus, P. Lienau, A. Reichel, W. Huisinga
Zeitschrift: J Biomol Screen. Seiten: 913-923 Band: 14 Link zur Publikation , Suppl Material

2009 | Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t-complex-responder | N. Véron, H. Bauer, A. Y. Weiße, G. Lüder, M. Werber, and B. G. Herrmann
Zeitschrift: Genes & Development Seiten: 2705-10 Band: 23 Link zur Publikation

2008 | A dynamical low-rank approach to the chemical master equation | T. Jahnke, and W. Huisinga
Zeitschrift: Bull. Math. Biol. Seiten: 2283-2302 Band: 70 Link zur Publikation

2008 | Adaptive discrete Galerkin methods applied to the chemical master equation | P. Deuflhard, W. Huisinga, T. Jahnke, and M. Wulkow
Zeitschrift: SIAM J. Sci. Comput. Seiten: 2990-3011 Band: 30 Link zur Publikation

2007 | Hybrid stochastic and deterministic simulations of calcium blips | S. Rüdiger, J.W. Shuai, W. Huisinga, Ch. Nagaiah, G. Warnecke, I. Parker, M. Falcke
Zeitschrift: Biophys. J. Seiten: 1847-1857 Band: 93 Link zur Publikation

2007 | Physiologically based pharmacokinetic modelling: A sub-compartmentalized model of tissue distribution | M. von Kleist and W. Huisinga
Zeitschrift: J. Pharmacokinet. Pharmacodyn. Seiten: 789-806 Band: 34 Link zur Publikation

2007 | Optimizing Classification of Drug-Drug Interaction Potential for CYP450 Isoenzyme Inhibition Assays in Early Drug Discovery | B.-F. Krippendorff, P. Lienau, A. Reichel, W. Huisinga
Zeitschrift: J Biomol Screen Seiten: 92-99 Band: 12 Link zur Publikation

2007 | Solving the chemical master equation for monomolecular reaction systems analytically | T. Jahnke, W. Huisinga
Zeitschrift: J. Math. Biol. Seiten: 1-26 Band: 54 Link zur Publikation

2007 | Combining Systems Biology with physiologically-based pharmacokinetics to support the understanding of drug effects | M. von Kleist, C. Kloft and W. Huisinga
Zeitschrift: Proceedings of Foundations of Systems Biology in Engeneering FOSBE Seiten: 231-236

2006 | Computational Physiology | W. Huisinga
Zeitschrift: European Communications in Mathematical and Theoretical Biology, No. 8, January 2006 Seiten: 12-13 Band: 8 Link zur Publikation

2006 | The virtual lab approach to pharmacokinetic: Design principles and concepts | W. Huisinga, R. Telgmann, M. Wulkow
Zeitschrift: Drug Discov Today Seiten: 800-805 Band: 11 Link zur Publikation

2006 | Adaptive Approach for Modelling Variability in Pharmacokinetics | A. Weiße, I. Horenko, and W. Huisinga
Reihe: Lecture Notes in Computer Science Verlag: Springer Buchtitel: 'Computational Life Sciences II', M.R. Berthold, R. Glen, and I. Fischer (Eds.) Seiten: 194-204 Band: 4216 Link zur Publikation

2006 | Software Supported Modelling in Pharmacokinetics | R. Telgmann, M. von Kleist, and W. Huisinga
Reihe: Lecture Notes in Computer Science Verlag: Springer Buchtitel: 'Computational Life Sciences II', M.R. Berthold, R. Glen, and I. Fischer (Eds.) Seiten: 216-225 Band: 4216 Link zur Publikation

2005 | Adaptive simulation of hybrid stochastic and deterministic models for biochemical systems | A. Alfonsi, E. Cances, G. Turinici, B. Di Ventura, W. Huisinga
Zeitschrift: ESAIM: Proc. Seiten: 1-13 Band: 14 Link zur Publikation

2005 | Metastability and Dominant Eigenvalues of Transfer Operators | W. Huisinga, B. Schmidt
Reihe: Lecture Notes in Computational Science and Engineering Verlag: Springer Buchtitel: 'Advances in Algorithms for Macromolecular Simulation', C. Chipot, R. Elber, A. Laaksonen, B. Leimkuhler, A. Mark, T. Schlick, C. Schütte, and R. Skeel (Eds.) Band: 49 Link zur Publikation

2005 | Adaptive Approach for Non-Linear Sensitivity Analysis of Reaction Kinetics | I. Horenko, S. Lorenz, C. Schütte, W. Huisinga
Zeitschrift: J. Comp. Chem. Seiten: 941-948 Band: 26 Link zur Publikation

2005 | Internal exposure of children by simulated acute inhalation of volatile organic compounds: the influence of chemical properties on the child/adult concentration ratio | K. Abraham, H. Mielke, W. Huisinga, U. Gundert-Remy
Zeitschrift: Basic & Clinical Pharmacology & Toxicology Seiten: 242–243 Band: 96 Link zur Publikation

2005 | Elevated Internal Exposure of Children in Simulated Acute Inhalation of Volatile Organic Compounds: Effects of Concentration and Duration | K. Abraham, H. Mielke, W. Huisinga, U. Gundert-Remy
Zeitschrift: Arch Toxicol Seiten: 63-73 Band: 79 Link zur Publikation

2004 | An Averaging Principle for Fast Degrees of Freedom Exhibiting Long-Term Correlations | Ch. Schütte, J. Walter, C. Hartmann, W. Huisinga
Zeitschrift: SIAM Multiscale Modeling and Simulation 2 Seiten: 501-526 Link zur Publikation

2004 | Phase Transitions & Metastability in Markovian and Molecular Systems | W. Huisinga, S. Meyn, Ch. Schütte
Zeitschrift: Ann. Appl. Probab. Seiten: 419-458 Band: 14 Link zur Publikation

2003 | Metastability of Diffusion Processes | Ch. Schütte, W. Huisinga, S. Meyn
Buchtitel: Proceeding of the IUTAM Symposium on Nonlinear Stochastic Dynamics (August 26 - August 30, 2002, Illinois/USA) Link zur Publikation

2003 | Extracting Macroscopic Stochastic Dynamics: Model Problems | W. Huisinga, Ch. Schütte, A. M. Stuart
Zeitschrift: Comm. Pure Appl. Math. Seiten: 234-269 Band: 56 Link zur Publikation

2003 | Biomolecular Conformations can be Identified as Metastable Sets of Molecular Dynamics | Ch. Schütte, W. Huisinga
Buchtitel: 'Handbook of Numerical Analysis' edited by P. G. Ciarlet, Special Volume: Computational Chemistry (Vol X) , guest editor C. Le Bris Link zur Publikation

2001 | Transfer Operator Approach to Conformational Dynamics in Biomolecular Systems | Ch. Schütte, W. Huisinga, P. Deuflhard
Buchtitel: 'Ergodic Theory, Analysis, and Efficient Simulation of Dynamical Systems' edited by B. Fiedler Seiten: 191-223 Link zur Publikation

2000 | Self-Organizing Maps Combined with Eigenmode Analysis for Automated Cluster Identification | T. Galliat, Wilhelm Huisinga, P. Deuflhard
Verlag: Academic Press Buchtitel: 'Neural Computation' edited by H. Bothe and R. Rojas, ICSC Seiten: 227-232 Link zur Publikation

2000 | On Conformational Dynamics induced by Langevin Processes | Ch. Schütte, W. Huisinga
Buchtitel: 'International Conference on Differential Equations (EquaDiff 99)', edited by B. Fiedler K. Gröger and J. Sprekels, Vol.2 (2000) Seiten: 1247-1262 Link zur Publikation

2000 | Biomolecular Conformations as Metastable Sets of Markov Chains | Ch. Schütte, W. Huisinga
Buchtitel: Proceedings of the 38th. Annual Allerton Conference on Communication, Control, and Computing, Oct. 4-6, Allerton House, Monticello, Illinoins/USA (2000) Seiten: 1106-1115 Link zur Publikation

2000 | Identification of Almost Invariant Aggregates in Reversible Nearly Uncoupled Markov Chains | P. Deuflhard, W. Huisinga, A. Fischer, Ch. Schütte
Zeitschrift: Lin. Alg. Appl. Seiten: 39-59 Band: 315 Link zur Publikation

1999 | From Simulation Data to Conformational Ensembles: Structure and Dynamics based Methods | W. Huisinga, Ch. Best, R. Roitzsch, Ch. Schütte, F. Cordes
Zeitschrift: J. Comp. Chem. Seiten: 1760-1774 Band: 20 Link zur Publikation

1999 | Faber and Newton Polynomial Integrators for Open-System Density Matrix Propagation | W. Huisinga, L. Pesce, R. Kosloff, P. Saalfrank
Zeitschrift: J. Chem. Phys. Seiten: 5538-5547 Band: 110 Link zur Publikation

1999 | A Direct Approach to Conformational Dynamics based on Hybrid Monte Carlo | Ch. Schütte, A. Fischer, W. Huisinga, P. Deuflhard
Zeitschrift: J. Comp. Phys. Seiten: 146-168 Band: 151 Link zur Publikation