Publikationen

2025 | Information‑theoretic evaluation of covariate distributions models | N. Hartung, A. Khatova
Zeitschrift: Journal of Pharmacokinetics and Pharmacodynamics Band: 52:21 Link zur Publikation

2024 | Leveraging QSP Models for MIPD: A Case Study for Warfarin/INR | U. Falkenhagen, L. H. Cavallari, J. D. Duarte, C. Kloft, S. Schmidt, W. Huisinga
Zeitschrift: Clinical Pharmacology & Therapeutics Seiten: 795-806 Band: 116(3) Link zur Publikation , Corrigendum

2024 | Understanding Voriconazole Metabolism: A Middle‑Out Physiologically‑Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights | A. Saleh, J. Schulz, J.‑F. Schlender, L. B. S. Aulin, A.‑P. Konrad, F. Kluwe, G. Mikus, W. Huisinga, C. Kloft, R. Michelet
Zeitschrift: Clinical Pharmacokinetics Link zur Publikation

2024 | A Hands-on Guide to AmoePy — a Python-Based Software Package to Analyze Cell Migration Data | T. Moldenhawer, D. Schindler, M. Holschneider, W. Huisinga, C. Beta
Reihe: Methods in Molecular Biology Verlag: Springer Nature Buchtitel: Cell Motility and Chemotaxis Seiten: 159-184 Band: 2828 Link zur Publikation

2024 | Novel mathematical approach to accurately quantify 3D endothelial cell morphology and vessel geometry based on fluorescently marked endothelial cell contours: Application to the dorsal aorta of wild-type and Endoglin-deficient zebrafish embryos | D. Seeler, N. Grdseloff, C. J. Rödel, C. Kloft, S. Abdelilah-Seyfried, W. Huisinga
Zeitschrift: PLoS Computational Biology Link zur Publikation

2024 | Calcium kinetic rates in Caucasian males and females from birth to adulthood | N. Hartung, S. A. Abrams, W. Huisinga, K. Weisser
Zeitschrift: Bone Link zur Publikation

2024 | Model reduction for Ca2+-induced vesicle fusion dynamics | A. Ernst, U. Falkenhagen, S. Winkelmann
Zeitschrift: Proceedings in Applied Mathematics and Mechanics Seiten: e202300184 Link zur Publikation

2024 | Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions | D. Schindler, T. Moldenhawer, C. Beta, W. Huisinga, M. Holschneider
Zeitschrift: PLoS One Link zur Publikation , Link zum Preprint

2024 | Index analysis: an approach to understand signal transduction with application to the EGFR signalling pathway | J. Knöchel, C. Kloft, W. Huisinga
Zeitschrift: PLoS Computational Biology Link zur Publikation , Link zum Preprint

2023 | Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data | F. Kluwe. R. Michelet, W. Huisinga, M. Zeitlinger, G. Mikus, C. Kloft
Zeitschrift: Clinical Pharmacokinetics Link zur Publikation

2023 | C-Reactive Protein as an Early Predictor of Efficacy in Advanced Non-Small-Cell Lung Cancer Patients: A Tumor Dynamics-Biomarker Modeling Framework | Y. M. Nassar, F. W. Ojara, A. Pérez-Pitarch, K. Geiger, W. Huisinga, N. Hartung, R. Michelet, S. Holdenrieder, M. Joerger, C. Kloft
Zeitschrift: Cancers Seiten: 5429 Band: 15(22) Link zur Publikation

2023 | Sample-based robust model reduction for non-linear systems biology models | U. Falkenhagen, C. Himpe, J. Knöchel, C. Kloft, W. Huisinga
Zeitschrift: Proceedings in Applied Mathematics & Mechanics Link zur Publikation

2023 | Deriving mechanism-based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin | U. Falkenhagen, J. Knöchel, C. Kloft, W. Huisinga
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Seiten: 432–443 Band: 12 Link zur Publikation

2023 | Model-Informed Target Morning 17α-Hydroxyprogesterone Concentrations in Dried Blood Spots for Pediatric Congenital Adrenal Hyperplasia Patients | V. Stachanow, U. Neumann, O. Blankenstein, N. Alder-Baerens, D. Bindellini, P. Hindmarsh, R.J. Ross, M.J. Whitaker, J. Melin, W. Huisinga, R. Michelet, C. Kloft
Zeitschrift: Pharmaceuticals Seiten: 464 Band: 16(3) Link zur Publikation

2023 | Cell-level systems biology model to study inflammatory bowel diseases and their treatment options | S. Stübler, C. Kloft, W. Huisinga
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology Seiten: 690-705 Band: 12 Link zur Publikation